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The Human Centipede tells the story of two American tourists, Lindsay (Ashley C. Williams) and Jenny (Ashlynn Yennie), who find themselves stranded in rural Germany. They stumble upon the home of Dr. Heiter (Dieter Laser), a former surgeon who has a twisted obsession with creating a human centipede. Heiter kidnaps the two women and subjects them to a grotesque surgical procedure, connecting them mouth-to-anus to create a horrific, three-person centipede.