The gameplay in Resident Evil 4 HD Edition remains largely unchanged from the original release. Players control Leon S. Kennedy as he searches for President's daughter, Ashley Graham, in a rural Spanish village infested by the Ganados, a cult-like group of zombie-like creatures. The game's combat system, which combines elements of third-person shooting and survival horror, is still tight and engaging. The game's inventory management system, which uses a briefcase with limited space, adds an extra layer of strategy to the gameplay.